C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/82 (2006.01) C07D 279/16 (2006.01)
Patent
CA 2700584
The present invention relates to novel amidine, thiourea and guanidine derivatives of appropriately substituted 2-aminobenzothiazoles, 2-amino-3,1-4H-benzothiazines and 3- amino-1,4-3H-benzothiazines, as understood from formula (I), the related pharmaceutically acceptable salts and solvates thereof: Formula (I): and the use of said products and the corresponding pharmaceutical formulations for the treatment of neurodegenerative pathologies such as cerebral ischemia, neurodegeneration induced by cranial trauma, Alzheimer's disease, Multiple Sclerosis and Amyotrophic Lateral Sclerosis.
La présente invention concerne de nouveaux dérivés amidine, thiourée et guanidine de 2-aminobenzothiazoles, 2-amino-3,1-4H-benzothiazines et 3-amino-l,4-3H-benzothiazines substitutés de manière appropriée, comme le montre la formule (I), leurs sels et solvates pharmaceutiquement acceptables : Formule (I) : et l'utilisation desdits produits et des préparations pharmaceutiques correspondantes pour le traitement de pathologies neurodégénératives, telles que l'ischémie cérébrale, une neurodégénérescence induite par un traumatisme crânien, la maladie d'Alzheimer, la sclérose en plaques et la sclérose latérale amyotrophique.
Anzini Maurizio
Cappelli Andrea
Caselli Gianfranco
Giordani Antonio
Makovec Francesco
Macrae & Co.
Rottapharm S.p.a.
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