Amidino protease inhibitors

Details Amidino protease inhibitors Amidino protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 211/22 (2006.01) A61K 31/18 (2006.01) A61K 31/255 (2006.01) A61K 31/435 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07C 309/73 (2006.01) C07C 311/21 (2006.01) C07D 211/26 (2006.01) C07D 211/28 (2006.01) C07D 213/61 (2006.01) C07D 215/16 (2006.01) C07D 295/195 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2256309

Amidino and benzamidino compounds, including compounds of Formula (I), wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula (I).

L'invention concerne des composés amidino et benzamidino, parmi lesquels des composés de formule (I), où R<1>-R<4>, R<6>-R<9>, Y, Z, n et m sont tels qu'exposés dans la description, ainsi que leurs hydrates, solvates ou sels pharmaceutiquement acceptables, qui inhibent de nombreux enzymes protéolytiques. L'invention concerne également des procédés permettant de préparer les composés de formule (I).

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