C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/00 (2006.01) C07D 223/02 (2006.01) C07D 223/04 (2006.01) C07D 231/04 (2006.01)
Patent
CA 2565238
The present invention relates to inhibitors of 11-.szlig. hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-.szlig. hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
La présente invention concerne des inhibiteurs de 11-â hydroxystéroïde déshydrogénase de type 1, des antagonistes du récepteur minéralocorticoïde (MR), et des compositions pharmaceutiques de ceux-ci. Les composés de l~invention peuvent être utiles dans le traitement de diverses maladies associées à l~expression ou l~activité de la 11-â hydroxystéroïde déshydrogénase de type 1 et/ou de maladies associées à un excès d~aldostérone.
He Chunhong
Metcalf Brian
Qian Ding-Quan
Xu Meizhong
Yao Wenqing
Incyte Corporation
Smart & Biggar
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