Amidopyrazole derivative

Details Amidopyrazole derivative Amidopyrazole derivative

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2551604

A platelet aggregation inhibitor not inhibiting COX-1 and COX-2, comprised of a compound of the general formula: (I) (wherein each of Ar1 and Ar2 independently represents a 5- or 6-membered aromatic heterocycle optionally having one to three substituents, or phenyl optionally having one to three substituents; R1 is a lower acyl, carboxyl, a lower alkoxycarbonyl, a lower alkyl optionally having one or two substituents, carbamoyl optionally having one or two substituents, oxamoyl optionally having one or two substituents, amino optionally having one or two substituents, a 4- to 7-membered alicyclic heterocycle optionally having one or two substituents, phenyl optionally having one to three substituents, or a 5- or 6-membered aromatic heterocycle optionally having one to three substituents; and R2 is hydrogen, a halogeno, etc.).

L'invention porte sur un inhibiteur de l'agrégation des plaquettes qui n'inhibe ni COX-1 ni COX-2, et qui comprend un composé de la formule générale (1) : (dans laquelle chacun de Ar¿1 ?et Ar¿2? représente indépendamment un hétérocycle aromatique à 5 ou 6 chaînons comprenant facultativement de un à trois substituants, ou un phényle comprenant facultativement de un à trois substituants ; R?1¿ est un acyle inférieur, un carboxyle, un alcoxycarbonyle inférieur, un alkyle inférieur comprenant facultativement de un à deux substituants, un carbomoyle comprenant facultativement de un à deux substituants, un oxamoyle comprenant facultativement de un à deux substituants, un amino comprenant facultativement de un à deux substituants, un hétérocycle alicyclique de 4 à 7 chaînons comprenant facultativement de un à deux substituants, un phényle comprenant facultativement de un à trois substituants, ou un hétérocycle aromatique à 5 ou 6 chaînons comprenant facultativement de un à trois substituants ; et R?2¿ est un hydrogène, un halogéno, etc.).

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