Amine salts of (-)-2-{2-(4-hydroxyphenyl)...

Details Amine salts of (-)-2-{2-(4-hydroxyphenyl)... Amine salts of (-)-2-{2-(4-hydroxyphenyl)...

C - Chemistry, Metallurgy

07

C

C07C 323/56 (2006.01) A61K 31/192 (2006.01)

Patent

CA 2529544

A tert-butylamine salt, a piperazine salt, a choline salt, a tris(hydroxymethyl)methylamine salt, a lysine salt or an adamantylamine salt of (-)-2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4- [(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]propanoic acid processes for their preparation, their use in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance and other manifestations of the metabolic syndrome, and pharmaceutical compositions containing them.

Cette invention concerne un sel <i>tert</i>-butylamine, un sel pipérazine, un sel choline, un sel tris(hydroxyméthyl)méthylamine, un sel lysine ou un sel adamantylamine d'acide (-)-2-{[2-(4-hydroxyphényl)éthyl]thio}-3-[4-(2-{4-[(méthylsulfonyl)oxy]phénoxy}éthyl)phényl]propanoïque, des procédés de préparation de ces sels, leur utilisation pour traiter des états cliniques, notamment des troubles du métabolisme lipidique (dyslipidémies) associés ou non à une résistance à l'insuline et d'autres manifestations du syndrome métabolique, et à des compositions contenant ces sels.

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