Amino acid sequences directed against gpcrs and polypeptides...

C - Chemistry – Metallurgy – 07 – K

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2673331

The present invention relates to amino acid sequences that are directed G-protein coupled receptors (GPCRs), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes mentioned herein.

La présente invention concerne des séquences d'acides aminés qui sont dirigées contre les récepteurs couplés à la protéine G (GPCR), aussi bien que des composés ou des constructions, et en particulier des protéines et des polypeptides, qui contiennent ou sont sensiblement constitués d'une ou de plusieurs séquences d'acides aminés de ce type. L'invention concerne également des acides nucléiques codant pour de telles séquences d'acides aminés et de tels polypeptides, des procédés permettant de préparer de telles séquences d'acides aminés et de tels polypeptides ; des cellules hôtes exprimant ou susceptibles d'exprimer de telles séquences d'acides aminés ou de tels polypeptides ; des compositions, et en particulier des compositions pharmaceutiques, qui renferment des séquences d'acides aminés, polypeptides, acides nucléiques et/ou des cellules hôtes de ce type. L'invention concerne également les utilisations de séquences d'acides aminés ou de polypeptides, acides nucléiques, cellules hôtes et/ou compositions de ce type, en particulier à des fins prophylactiques, thérapeutiques ou diagnostiques, telles que les fins prophylactiques, thérapeutiques ou diagnostiques décrites dans le présent document.

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