Amino derivatives of 3-alkyl-5-(2-hydroxystyryl)- isoxazoles

Details Amino derivatives of 3-alkyl-5-(2-hydroxystyryl)- isoxazoles Amino derivatives of 3-alkyl-5-(2-hydroxystyryl)- isoxazoles

C - Chemistry, Metallurgy

07

D

260/311.9

C07D 261/08 (2006.01)

Patent

CA 1128051

ABSTRACT OF THE DISCLOSURE: Alkylamino-propanol derivatives of 3-alkyl-5- (2-hydroxystyryl)-isoxazole, of the general formula Image where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cyclo- alkyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and R' is alkyl of 1 to 4 carbon atoms, and their addition salts with physiologically acceptable acids, their preparation, and pharmaceutical formulations which contain these compounds and which can be used as valuable drugs in the treatment of hypertonia, coronary diseases of the heart and cardiac arrhythmias.

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