Amino ester derivatives, salts thereof and methods of use

Details Amino ester derivatives, salts thereof and methods of use Amino ester derivatives, salts thereof and methods of use

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/47 (2006.01) A61P 35/00 (2006.01) C07D 215/22 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2752421

The present invention provides amino ester compounds, salts, and pharmaceutical formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

La présente invention concerne des composés ester d'amino, des sels, et des formulations pharmaceutiques de ceux-ci utiles dans la modulation de l'activité protéine tyrosine kinase, et dans la modulation de la signalisation inter- et/ou intra-cellulaire. L'invention concerne en outre des compositions pharmaceutiquement acceptables comprenant de tels composés et des procédés d'utilisation des compositions dans le traitement de troubles hyperprolifératifs chez des mammifères, en particulier des humains.

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