C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/435 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 239/00 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2326383
Disclosed are compounds of formula (I), wherein Ar, Q1, Q2, R1, W and X are substituents as defined herein, which compounds are water-soluble CRF1 receptor antagonists, and are therefore useful for the treatment of psychiatric disorders and neurological diseases, including major depression, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders, as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
L'invention concerne des composés de la formule (I) dans laquelle Ar, Q?1¿, Q?2¿, R?1¿, W et X sont des substituants tels que définis dans la présente invention, ces composés étant des antagonistes de récepteurs de CRF1 solubles dans l'eau, et s'utilisant de ce fait pour le traitement de troubles psychiatriques et d'affections neurologiques, y compris la dépression grave, les troubles en rapport avec l'anxiété, le syndrome de stress post-traumatique, la paralysie supranucléaire et les troubles de l'alimentation, ainsi que pour le traitement d'affections immunologiques, cardiovasculaires ou cardiaques, et de l'hypersensibilité du côlon associée à un trouble psychopathologique et au stress.
de Lombaert Stephane
Ge Ping
Horvath Raymond F.
Mbm & Co.
Neurogen Corporation
LandOfFree
Aminoalkyl substituted pyrrolo¬2,3-b|pyridine and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aminoalkyl substituted pyrrolo¬2,3-b|pyridine and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminoalkyl substituted pyrrolo¬2,3-b|pyridine and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1674803