Aminoheterocyclic derivatives as antithrombotic or...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/04 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 213/74 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2197471

The invention concerns compounds of formula (I), wherein each of G1, G2 and G3 is CH or N; m is 1 or 2; R1 includes hydrogen, halogeno and (1-4C)alkyl; M1 is a group of formula: NR2-L1-T1R3, in which R2 and R3 together form a (1- 4C)alkylene group, L1 includes (1-4C)alkylene, and T1 is CH or N; A may be a direct link; M2 is a group of the formula: (T2R4)r-L2-T3R5 in which R is 0 or 1, each of T2 and T3 is CH or N, each of R4 and R5 is hydrogen or (1-4C)alkyl, or R4 and R5 together form a (1-4C)alkylene group, and L2 includes (1- 4C)alkylene; M3 may be a direct link to X; X includes sulphonyl; and Q includes naphthyl and a heterocyclic moiety; or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use as antithrombotic or anticoagulant agents.

L'invention concerne des composés représentés par la formule (I) dans laquelle chacun de G?1¿, G?2¿ et G?3¿ représente CH ou N; m est 1 ou 2; R?1¿ comprend hydrogène, halogéno et (1-4C)alkyle; M?1¿ représente un groupe de formule: NR?2¿-L?1¿-T?1¿R?3¿, dans laquelle R?2¿ et R?3¿ constituent un groupe (1-4C)alkylène, L?1¿ comprend (1-4C)alkylène et T?1¿ représente CH ou N; A peut être une liaison directe; M?2¿ représente un groupe de formule: (T?2¿R?4¿)¿r?-L?2¿-T?3¿R?5¿, dans laquelle r est 0 ou 1, chacun de T?2¿ et de T?3¿ représente CH ou N, chacun de R?4¿ et de R?5¿ représente hydrogène ou (1-4C)alkyle ou R?4¿ et R?5¿ constituent ensemble un groupe (1-4C)alkylène et L?2¿ comprend (1-4C)alkylène; M?3¿ peut représenter une liaison directe avec X; X comprend sulfonyle et Q comprend naphthyle et une fraction hétérocyclique; ou un de leurs sels pouvant s'utiliser en pharmacie; procédés servant à les préparer, compositions pharmaceutiques les contenant et leur utilisation en tant qu'agents antithrombotiques ou anticoagulants.

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