C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/497 (2006.01) A61K 31/5513 (2006.01) A61P 27/06 (2006.01) C07D 241/14 (2006.01) C07D 403/04 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2590261
Methods for using aminopyrazine analogs of formula (I): (see formula I) to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of aminopyrazine analogs, are also disclosed.
L'invention concerne des méthodes visant à utiliser des analogues d'aminopyrazine afin de traiter des maladies ou des états médiés par rho kinase, ainsi que de contrôler la pression intra-oculaire et traiter le glaucome. Elle concerne également des compositions pharmaceutiques ophtalmiques utiles pour traiter des maladies oculaires, telles que le glaucome et également utiles pour contrôler la pression intra-oculaire, ces compositions contenant une quantité efficace d'analogues d'aminopyrazine.
Decornez Helene Y.
Guo Cheng
Hadden Mark
Hellberg Mark R.
Henderson Alan J.
Alcon Inc.
Kirby Eades Gale Baker
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