C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 41/00 (2006.01) A61K 31/575 (2006.01) G01N 33/48 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2223910
Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
Composés d'aminostérol utiles comme inhibiteurs de l'échangeur sodium/proton (NHE). Sont également décrits des procédés d'utilisation de ces composés d'aminostérols, y compris des procédés prévoyant l'utilisation de composés qui sont des inhibiteurs d'un spectre de NHE et ceux qui utilisent des composés inhibiteurs d'un seul NHE spécifique. L'invention concerne également des techniques et des dosages de décriblage permettant d'évaluer l'activité thérapeutique d'un composé.
Anderson Mark
Jones Steven
Kinney William
Mclane Michael
Rao Meena
Genaera Corporation
Magainin Pharmaceuticals Inc.
Ridout & Maybee Llp
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