A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/32 (2006.01) C12N 5/077 (2010.01) A61P 19/00 (2006.01) A61P 19/02 (2006.01)
Patent
CA 2575137
Provided are compositions and methods for in vitro generation and in vivo use of tissue for the repair of defective tissue, especially cartilage. Chondrocytes or other cells are cultured in vitro in a biodegradable amorphous carrier within the confines of a space bounded by a semi-permeable membrane with a molecular weight cut-off of greater than 100 kDa. The culture can be subjected to physical/physicochemical conditions that mimic in vivo conditions of the tissue in need of repair or replacement. In one embodiment the invention provides an amorphous preparation of chondrocytes and their extracellular products, suitable for injection.
L'invention concerne des compositions et procédés destinés à la génération in vitro et l'utilisation in vivo de tissus permettant de réparer un tissu défectueux notamment un cartilage. Des chondrocytes ou d'autres cellules sont cultivés in vitro dans un support amorphe biodégradable dans les limites d'un espace délimité par une membrane semi-perméable à seuil de coupure moléculaire excédant 100 kDa. La culture peut être soumise à des états physiques/physico-chimiques qui imitent les états in vivo des tissus devant être réparés ou remplacés. Dans un mode de réalisation, l'invention concerne une préparation amorphe de chondrocytes et leurs produits extracellulaires, convenant à l'injection.
Brigham And Women's Hospital Inc.
Smart & Biggar
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