An agent for inducing apoptosis

Details An agent for inducing apoptosis An agent for inducing apoptosis

C - Chemistry, Metallurgy

07

D

C07D 307/93 (2006.01) A61K 31/00 (2006.01) A61K 31/34 (2006.01) A61K 31/365 (2006.01) A61K 31/70 (2006.01) C07D 407/14 (2006.01) C07D 493/08 (2006.01) C07H 17/08 (2006.01)

Patent

CA 2342325

Apoptosis inducing agents which contain as the active ingredient tetrocarcin derivatives represented by general formula (I) or salts thereof. These agents are useful as drugs for preventing and/or treating diseases caused by the accelerated expression of proteins of the Bc1-2 family such as cancer and AIDS; wherein <u>---</u> represents a single or double bond; j and k are each 0 or 1; R1 to R3, R7 to R10 and R14 represent each hydrogen, lower alkyl, etc.; R4, R11, R12, R13 and R15 to R18 represent each hydrogen, hydroxy, lower alkyl, etc.; R5 and R6 represent each hydrogen, hydroxy, lower alkyl or (B) (wherein R32 represents formyl, etc.; and R33 to R35 represent each hydrogen, hydroxy, lower alkyl, etc.); and R19 represents hydroxy, lower alkoxy, lower alkanoyloxy, etc.

Cette invention concerne des agents induisant l'apoptose qui contiennent en qualité d'ingrédient actif des dérivés de tetrocarcine correspondant à la formule générale (I) où: <u>---</u> représente une liaison simple ou double; j et k représentent chacun 0 ou 1; R?1¿ à R?3¿, R?7¿ à R?10¿ et R?14¿ représentent chacun hydrogène, alkyle inférieur, etc.; R?4¿, R?11¿, R?12¿, R?13¿ et R?15¿ à R?18¿ représentent chacun hydrogène, hydroxy, alkyle inférieur, etc.; R?5¿ et R?6¿ représentent chacun hydrogène, hydroxy, alkyle inférieur ou (B) dans laquelle R?32¿ représente formyle etc., tandis que R?33¿ à R?35¿ représentent chacun hydrogène, hydroxy, alkyle inférieur, etc.; et R?19¿ représente hydroxy, alcoxy inférieur, alcanoyloxy inférieur, etc. Cette invention concerne également des sels de ces agents. Ces agents peuvent être utilisés en qualité de médicaments afin de prévenir et/ou de traiter des maladies dues à l'expression accélérée de protéines de la famille Bc1-2, tel que le cancer ou le SIDA.

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