A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/55 (2006.01) A61K 31/165 (2006.01) A61K 31/167 (2006.01) A61K 31/19 (2006.01) A61K 31/336 (2006.01) A61K 31/40 (2006.01) A61K 31/407 (2006.01) A61K 31/4353 (2006.01) A61K 31/4406 (2006.01) A61K 45/00 (2006.01) A61P 19/02 (2006.01)
Patent
CA 2495354
An arthrodial cartilage extracellular matrix degradation inhibitor, which contains a compound inhibiting histone deacetylase as the active ingredient, is useful in preventing and treating diseases and pathological conditions in which the degradation and denaturation of arthrodial cartilage extracellular matrix participate, in particular, osteroarthritis, articular rheumatism, arthritis deformans, etc.
La présente invention se rapporte à un inhibiteur de dégradation de la matrice extracellulaire du cartilage arthrodial, qui contient en tant que principe actif un composé inhibant l'histone-désacétylase. Cet inhibiteur s'avère utile pour prévenir et traiter les maladies et les troubles pathologiques dans lesquels la dégradation et la dénaturation de la matrice extracellulaire du cartilage arthrodial jouent un rôle, en particulier, l'ostéo-arthrite, les rhumatismes articulaires, la polyarthrite rhumatoïde, etc..
Shindou Nobuaki
Terada Yoh
Yamaji Noboru
Astellas Pharma Inc.
Dennison Associates
Yamanouchi Pharmaceutical Co. Ltd.
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