C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 31/337 (2006.01) A61K 31/519 (2006.01) A61K 31/704 (2006.01) A61K 39/395 (2006.01) A61K 41/00 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2465040
An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of DR5 and DR4 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
La présente invention concerne un anticorps qui agit avec le DR5 ou DR4 de l'homme pour produire des effets agonistes ou antagonistes en aval du récepteur, comprenant l'inhibition de la prolifération cellulaire et de l'apoptose. Des séquences d'acides nucléiques et des séquences d'acides aminés d'anticorps DR5 et DR4 ont été élucidées et des vecteurs et des cellules contenant et exprimant ces séquences ont été générées. L'invention a également pour objet des procédés et des utilisations pour les anticorps qui comprennent les maladies liées à l'apoptose et le traitement des troubles de la croissance cellulaire.
Buchsbaum Donald J.
Kimberly Robert P.
Koopman William J.
Lobuglio Albert F.
Zhou Tong
Gowling Lafleur Henderson Llp
The Uab Research Foundation
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