Anf analogue

Details Anf analogue Anf analogue

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/22 (2006.01) A61K 38/38 (2006.01) A61K 47/48 (2006.01) A61P 9/10 (2006.01) A61P 13/12 (2006.01) C07K 14/58 (2006.01) C07K 14/765 (2006.01) C07K 19/00 (2006.01) C12N 1/19 (2006.01) C12N 15/12 (2006.01) C12N 15/16 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2562249

A fusion protein comprising an arterial natriuretic factor (ANF) amino acid sequence linked to an albumin amino acid sequence by one or more peptide bonds is provided. The ANF amino acid sequence may be linked to the N-terminal, the C-terminal, or both the N-terminal and the C-terminal of the albumin amino acid sequence. Also provided is a nucleic acid molecule encoding the fusion protein and a vector comprising the nucleic acid molecule. Methods for treating or preventing cardiovascular or renal disease comprising administration of an effective amount of the fusion protein, or nucleic acid encoding the fusion protein, are also disclosed.

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