Antagonists of mcp-1 function and methods of use thereof

Details Antagonists of mcp-1 function and methods of use thereof Antagonists of mcp-1 function and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/437 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/535 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61K 31/5513 (2006.01) A61K 45/06 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) C07D 498/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2432997

The present invention relates to chemical compounds of Formula (I) or (II) (wherein Y, Z and R1 - R6 are defined herein), pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, methods of treatment employing said compounds and compositions, and processes for preparing said compounds. Specifically, this invention relates to novel compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases. More specifically, the invention is related to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases.

L'invention concerne des composés chimiques, des compositions pharmaceutiques renfermant lesdits composés, diverses utilisations relatives aux composés et aux compositions considérés, des procédés de traitement reposant sur l'utilisation des mêmes composés et compositions, et des procédés relatifs à l'élaboration des composés en question. Spécifiquement, l'invention concerne de nouveaux composés antagonistes vis-à-vis de la fonction MCP-1, utiles dans la prévention ou le traitement de maladies inflammatoires ou auto-immunes chroniques ou aiguës, en particulier les maladies associées à l'accumulation de lymphocytes ou de monocytes de type aberrant, à savoir par exemple: arthrite, asthme, athérosclérose, néphropathie diabétique, maladie intestinale inflammatoire, maladie de Crohn, sclérose en plaques, néphrite, pancréatite, fibrose pulmonaire, psoriasis, resténose, et rejet du greffon. Plus spécifiquement, l'invention concerne des compositions pharmaceutiques renfermant les composés décrits, et l'utilisation de ces composés et compositions dans la prévention ou le traitement des maladies considérées.

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