Anti-cancer drugs, and uses relating for malignant melanoma...

C - Chemistry – Metallurgy – 07 – D

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C07D 345/00 (2006.01) A61K 31/33 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01) C07D 517/04 (2006.01) C07D 517/14 (2006.01)

Patent

CA 2759519

Selenopheno triazene analogs, their compositions, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, and pharmaceutically acceptable salts and mixtures thereof are useful for the treatment of metastatic malignant melanoma and other cancers. The selenopheno triazene analogs have the general formulae (I) or (II): wherein the substituents R1, R2, R3, R6, and R7 are as described in the specification. Other cancers include which may be treated with these compounds include, but are not limited to, malignant melanoma, leukemia, lymphomas (Hodgkins and non-Hodgkins), sarcomas (Ewing's sarcoma), brain tumors, central nervous system (CNS) metastases, gliomas, carcinomas such as breast cancer, prostate cancer, lung cancer (small cell and non-small cell), colon cancer, pancreatic cancer, Head and Neck cancers and oropharyngeal squamous cell carcinoma.

L'invention porte sur des analogues du sélénophénotriazène, sur leurs compositions, formes tautomères, stéréo-isomères, polymorphes, hydrates, solvates et sels pharmaceutiquement acceptables et mélanges correspondants, qui sont utiles pour le traitement d'un mélanome malin métastasique et d'autres cancers. Les analogues du sélénophénotriazène présentent les formules générales (I) ou (II) : dans lesquelles les substituants R1, R2, R3, R6 et R7 sont tels que décrits dans la description. D'autres cancers qui peuvent être traités par ces composés comprennent, mais sans y être limités, un mélanome malin, une leucémie, des lymphomes (Hodgkins et non Hodgkins), des sarcomes (sarcome d'Ewing), des tumeurs cérébrales, des métastases du système nerveux central (SNC), des gliomes, des carcinomes, tels que le cancer du sein, le cancer de la prostate, le cancer du poumon (à petites cellules et non à petites cellules), le cancer du côlon, le cancer pancréatique, le cancer de la tête et du cou et le carcinome cellulaire squameux oropharyngé.

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