Anti-ccr4 antibodies and methods of use therefor

Details Anti-ccr4 antibodies and methods of use therefor Anti-ccr4 antibodies and methods of use therefor

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C12N 5/20 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2358693

The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 4 (CCR4) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR4 with a ligand thereof, and to use of the antibodies and fragments in research, therapeutic, prophylactic and diagnostic methods.

L'invention concerne un anticorps ou un fragment fonctionnel dudit anticorps, qui se fixe sur le récepteur des chimiokines CC 4 (CCR4) de mammifère (par exemple l'homme) ou sur une partie dudit récepteur et qui empêche la fixation d'un ligand sur ledit récepteur. Elle concerne également une technique qui permet d'inhiber l'interaction d'une cellule portant un récepteur CCR4 de mammifère avec le ligand dudit récepteur, ainsi que l'utilisation desdits anticorps et fragments dans les domaines de la recherche, de la thérapeutique, de la prophylaxie et du diagnostic.

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