Anti-diabetic agents

Details Anti-diabetic agents Anti-diabetic agents

C - Chemistry, Metallurgy

07

D

C07D 209/42 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2521962

The invention provides compounds of formula (I) the prodrugs thereof, and the pharmaceutically acceptable salts of the compounds and prodrugs; wherein R', R", R"', X, and Z are as defined herein; pharmaceutical compositions thereof; and uses thereof in treating diabetes, insulin resistance, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis, and tissue ischemia.

La présente invention a trait à des composés de formule (I), dans laquelle : R', R'', R''', X et Z sont tels que définis dans la description. L'invention a également trait à leurs promédicaments, et aux sels pharmaceutiquement acceptables des composés et des promédicaments, et à leur utilisation dans le traitement du diabète, la résistance à l'insuline, la neuropathie diabétique, la néphropathie diabétique, la rétinopathie diabétique, les cataractes, l'hyperglycémie, l'hypercholestérolémie, l'hypertension, l'hyperinsulinémie, l'hyperlipémie, l'athérosclérose et l'ischémie tissulaire.

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