C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/18 (2006.01) A61K 39/395 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2137638
The present invention is related to the field of immunology, particularly the generation and selection of monoclonal antibodies (mAbs) against gangliosides (Abls) which antibodies are specific, have recurrent idiotypes and have value as immunoregulators of the immune response against those antigens, and to obtaininganti-idiotypic mAbs (Ab2s) generated by the immunization with the said anti ganglioside mAbs. Accordingly, an objective of this invention is to provide anti ganglioside mAbs (Abls) with idiotypes capable of inducing an antigen specific response (Abl') in the absence of the antigen and the methods for its generation. Another objective of this invention is to provide anti-idiotypic mAbs (Ab2s) generated by immunization with anti ganglioside mAbs that have the above mentioned property and also capable of producing all Abl' response. A further objective of the invention comprises generating specific anti ganglioside mAbs (Abl, immunizing mice and other species with said antibodies and selecting those antibodies capable of generating an antigen specific response (Abl'): generating anti-idiotypic mAbs by immunizing mice or other animal species with aforementioned anti ganglioside mAbs. It will be understood that where the term antibodies is used herein that fragments, derivatives and the like which have similar antigen grinding properties are also intended. Many ways of arriving at derivatives and/or fragments are known in the Art. Ways of producing derivatives and/or fragments include but are not limited to chemical cleavage and/or (re) assembly, recombinant production of single chain antibodies and/or molecular recognition units (MRU's), CDR-grafting class switches, etc.
Abraham Amparo E. M.
Fernandez Angel M. A.
Lopez Ana M. V.
Rodriguez Rolando P.
Ruiz Maria E. L.
Centro de Inmunologia Molecular
Macrae & Co.
LandOfFree
Anti gangliosides monoclonal antibodies and their use in the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti gangliosides monoclonal antibodies and their use in the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti gangliosides monoclonal antibodies and their use in the... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1841140