C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 14/18 (2006.01) C07K 16/10 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) G01N 33/576 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2339045
Described are novel antibodies specifically recognizing conformation dependent epitopes of HCV glycoprotein E2 and that are capable of neutralizing the binding of E2 protein onto susceptible cells. Furthermore, antigens and epitopes recognized by the above-described antibodies as well as polynucleotides encoding said antibodies are provided. Also provided are to vectors comprising said polynucleotides as well as host cells transformed therewith and their use in the production of said antibodies. In addition, pharmaceutical and diagnostic compositions are provided comprising any of the aforedescribed antibodies, antigens, epitopes, polynucleotides, vectors or cells. Further described is the use of the aforementioned antibodies, antigens, polynucleotides and vectors in adoptive immunotherapy, preferably for the treatment or prevention of HCV infection during liver transplantation.
L'invention porte sur: de nouveaux anticorps reconnaissant spécifiqquenent en fonction de la conformation des épitopes de la glycoprotéine E2 du VHC et capables de neutraliser la fixation de la protéine E2 sur des cellules susceptibles; sur des antigènes et épitopes reconnus par les anticorps ci-dessus et sur des polynucléotides codant pour ces mêmes anticorps; sur des vecteurs comprenant lesdits polynucléotides ainsi que des cellules hôtes transformées par eux et leur emploi pour la production d'anticorps; sur des préparations pharmaceutiques et diagnostiques comprenant les anticorps, antigènes, épitopes, polynucléotides, vecteurs ou cellules ci-dessus; et sur l'utilisation des susdits anticorps, antigènes, polynucléotides et vecteurs dans des immunothérapies adoptives de préférence pour le traitement ou la prévention des infections par le VHC lors de transplantations du foie.
Desgranges Claude
Fournillier Anne
Habersetzer Francois
Inchauspe Genevieve
Reiter Christian
Connex Gesellschaft Zur Optimierung von Forschung Und Entwicklun
Genmab A/s
Institut National de La Sante Et de La Recherche Medicale (inser
Ridout & Maybee Llp
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