C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 37/02 (2006.01) C12N 5/16 (2006.01)
Patent
CA 2707026
Human anti-human IL-21 monoclonal antibodies and the hybridomas that produce them are presented. Certain of these antibodies have the ability to bind native human IL-21, a mutant recombinat IL-21 protein and/or peptide regions of human IL-21. These human anti-IL-21 antibodies are useful in therapeutic treatment of autoimmune and inflammatory diseases, particularly diseases mediated by T follicular helper cells, B cells T H cells or T H17 cells.
L'invention concerne des anticorps monoclonaux anti-IL-21 humain et l'hybridome qui les produit. Certains de ces anticorps peuvent se lier au récepteur humain natif IL-21, à une protéine IL-21 recombinante mutante et/ou à des régions peptidiques de IL-21 humain. Ces anticorps anti-IL-21 humain sont utiles dans le traitement thérapeutique de maladies auto-immunes et inflammatoires, en particulier des maladies médiées par des cellules assistantes folliculaires T, des cellules B, des cellules TH ou des cellules TH17.
Dillon Stacey R.
Jaspers Stephen R.
Krejsa Cecile M.
Ramsdell Frederick J.
Rixon Mark W.
Smart & Biggar
Zymogenetics Inc.
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