Anti-human il-21 monoclonal antibodies

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 37/02 (2006.01) C12N 5/16 (2006.01)

Patent

CA 2707026

Human anti-human IL-21 monoclonal antibodies and the hybridomas that produce them are presented. Certain of these antibodies have the ability to bind native human IL-21, a mutant recombinat IL-21 protein and/or peptide regions of human IL-21. These human anti-IL-21 antibodies are useful in therapeutic treatment of autoimmune and inflammatory diseases, particularly diseases mediated by T follicular helper cells, B cells T H cells or T H17 cells.

L'invention concerne des anticorps monoclonaux anti-IL-21 humain et l'hybridome qui les produit. Certains de ces anticorps peuvent se lier au récepteur humain natif IL-21, à une protéine IL-21 recombinante mutante et/ou à des régions peptidiques de IL-21 humain. Ces anticorps anti-IL-21 humain sont utiles dans le traitement thérapeutique de maladies auto-immunes et inflammatoires, en particulier des maladies médiées par des cellules assistantes folliculaires T, des cellules B, des cellules TH ou des cellules TH17.

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