Anti-il-12 antibodies, epitopes, compositions, methods and uses

Details Anti-il-12 antibodies, epitopes, compositions, methods and uses Anti-il-12 antibodies, epitopes, compositions, methods and uses

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61P 1/00 (2006.01) A61P 17/06 (2006.01) A61P 25/00 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01) C07K 16/42 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2591813

An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

L'invention concerne un anticorps anti-IL-12 se liant à une partie de la protéine IL-12 correspondant à au moins un résidu d'acide aminé choisi dans le groupe constitué par les résidus 15, 17-21, 23, 40-43, 45-47, 54-56 et 58-62 de la séquence d'acides aminés de la sous-unité p40 d'IL-12, ainsi que des acides nucléiques isolés codant au moins un anticorps anti-IL-12, des vecteurs, des cellules hôtes, des animaux ou des plantes transgéniques, ainsi que des procédés de fabrication et d'utilisation associés trouvant des applications dans des compositions, des méthodes et des dispositifs diagnostiques et/ou thérapeutiques.

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