Anti-microbial-adhesion fraction derived from vaccinium

Details Anti-microbial-adhesion fraction derived from vaccinium Anti-microbial-adhesion fraction derived from vaccinium

A - Human Necessities

01

N

A01N 25/02 (2006.01) A61K 31/00 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2345242

A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium) plant genus (Fig. 1). In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight >=14,000; an elemental analysis of carbon 43-51 %, hydrogen 4-5 %, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in Figures 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and Helicobacter pylori.

L'invention concerne une composition anti-agrégation et anti-adhérence microbiennes non alimentaire, qui comporte un excipient approprié et une quantité efficace d'une fraction inhibitrice d'adhérence isolée à partir de jus de baies du genre Vaccinium. Dans un mode de réalisation, la fraction anti-agrégation et anti-adhérence isolée provient de jus de canneberges. Elle est caractérisée par ses propriétés polymères et son poids moléculaire >=14,000; une analyse élémentaire comprenant 43-51 % de carbone, 4-5 % d'hydrogène, pas d'azote, pas de soufre et pas de chlore; un spectre linéaire de résonance magnétique nucléaire (RMN) présenté dans les figures 2A et 2B; et un spectre ultraviolet présentant un pic d'absorption à 280 nm dans une solution neutre ou à pH acide, qui est absent dans des solutions alcalines. Cette fraction présente une activité inhibitrice d'adhérence à l'égard de bactéries à pili P, de bactéries buccales et d'Helicobacter pylori.

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