Anti mif antibodies

Details Anti mif antibodies Anti mif antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 1/00 (2006.01) A61P 13/12 (2006.01) A61P 35/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2711029

The present application relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The application also relates to isolated heavy and light chain immunoglobulins derived from anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present application also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.

La présente invention porte sur des anticorps monoclonaux et des parties de liaison aux antigènes de ceux-ci qui se lient de façon spécifique à l'extrémité C-terminale ou à la région centrale du facteur d'inhibition de la migration des macrophages (MIF). Ces anticorps anti-MIF et les parties de liaison aux antigènes de ceux-ci inhibent en outre la fonction biologique du MIF humain. La demande porte également sur des immunoglobulines à chaîne lourde et à chaîne légère isolées issues d'anticorps anti-MIF et sur des molécules d'acide nucléique codant pour de telles immunoglobulines. La présente demande porte également sur un procédé d'identification d'anticorps anti-MIF, sur des compositions pharmaceutiques comprenant ces anticorps et sur un procédé d'utilisation de ces anticorps et des compositions pour le traitement d'états se rapportant au MIF.

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