Antibiotic tetrahydro-.beta.-carboline derivatives

Details Antibiotic tetrahydro-.beta.-carboline derivatives Antibiotic tetrahydro-.beta.-carboline derivatives

A - Human Necessities

61

K

A61K 31/437 (2006.01) A61K 31/4355 (2006.01) A61P 9/00 (2006.01) A61P 15/10 (2006.01) C07D 207/36 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2524125

Disclosed are tetrahydro-.beta.-carboline derivatives such as structural formula I, pharmaceutical compositions comprising them and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatment and prevention of diseases caused by bacteria, particularly bacteria dependent on PPAT, for example, species such Escherichia coli, Helicobacter pylori, Staphyloccocus aureus, and the like. Description of the variables in structural formula I are provided herein.

L'invention concerne des dérivés de tétrahydro-.szlig.-carboline représentés par la formule développée (I), des compositions pharmaceutiques les contenant ainsi que des procédés permettant de traiter des infections bactériennes. Les composés de cette invention sont des inhibiteurs de PPAT (phosphopantéthéine adényl-transférase), et sont utiles pour le traitement et la prévention de maladies provoquées par des bactéries, plus spécifiquement des bactéries dépendant de la PPAT, par exemple, des espèces telles que Escherichia coli, Helicobacter pylori, Staphyloccocus aureus, et similaires. La description des variantes de la formule développée (I) est comprise dans le descriptif.

Affiliated with

Also associated with

Rating

Antibiotic tetrahydro-.beta.-carboline derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibiotic tetrahydro-.beta.-carboline derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibiotic tetrahydro-.beta.-carboline derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1606879