C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/22 (2006.01) A61K 39/395 (2006.01) A61P 25/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2761203
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
Cette invention concerne des anticorps anti-facteur de croissance nerveux (nGF) contenant une région constante IgG4 comprenant une mutation stabilisante d'une région charnière, lesdits anticorps présentant une demi-vie sérique chez le singe cynomolgus incroyablement longue. L'invention concerne également des compositions pharmaceutiques comprenant ces anti-anticorps anti-nGF, les acides nucléiques codant ces anticorps anti-nGF, des cellules hôtes exprimant ces anticorps anti-nGF et des méthodes d'utilisation des anticorps pour traiter des maladies ou des pathologies associées au nGF.
Best Andrea
Casson Duncan
Dutta Sandeep
Hall Jerry A.
Liu Wei
Abbott Research B.v.
Dennison Associates
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