Antibodies against pd-1 and uses therefor

Details Antibodies against pd-1 and uses therefor Antibodies against pd-1 and uses therefor

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 37/06 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2508660

This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.

L'invention concerne des anticorps et des fragments de liaison d'antigènes pouvant servir d'agonistes et/ou d'antagonistes de PD-1 (mort programmée 1), et moduler ainsi des réponses immunitaires en général, et plus particulièrement les réponses immunitaires à médiation par TcR et CD28. Les compositions et procédés selon l'invention peuvent par exemple servir au traitement de maladies auto-immunes, de maladies inflammatoires, d'allergies, de rejets de greffe, de cancers et d'autres maladies du système immunitaire.

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