Antibodies and fv fragment recognizing antigen ior c2

Details Antibodies and fv fragment recognizing antigen ior c2 Antibodies and fv fragment recognizing antigen ior c2

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/30 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2359577

The invention relates to the obtention of novel recombinant antibodies of novel recombinant antibodies from murine antibody ior C5 produced by the hybridome deposited under number ECCC 97061101 in accordance with the Budapest Treaty. Said recombinant antibodies were obtained using recombinant DNA technology and are characterized in that they recognize antigen ior C2. The recombinant antibodies are specifically chimeric antibody, humanized antibody and the single-chain Fv fragment. The chimeric antibody contains variable domains of murine immunoglobuline and the constant regions of human immunoglobuline. The humanized antibody contains the constant regions of human immunoglobuline and has been specifically modified in the murine framework regions (FRs) and within the latter, in those areas that may result in an antigenic site for cells T. The Fv fragment contains the variable domains of murine immunoglobuline. The invention also relates to the utilization of recombinant antibodies derived from murine antibody ior C5 in the diagnosis and therapy of colorectal tumors, the metastasis thereof and recurrences.

La présente invention concerne l'obtention de nouveaux anticorps recombinants à partir de l'anticorps murin ior C5 produit par l'hybridome qui a fait l'objet du dépôt numéro ECCC 97061101 selon le traité de Budapest. Lesdits anticorps recombinants, que l'on a obtenus par utilisation de la technologie de l'ADN recombiné, sont caractérisés en ce qu'ils reconnaissent l'antigène appelé ior C2. Ces anticorps recombinants sont notamment l'anticorps chimère, l'anticorps humanisé et le fragment du type Fv à chaîne simple. L'anticorps chimère contient les domaines variables de l'immunoglobuline murine et les régions constantes de l'immunoglobuline humaine. L'anticorps humanisé, qui contient les régions constantes de l'immunoglobuline humaine, a été modifié spécifiquement au niveau des régions charpente (framework regions) murines, et à l'intérieur de celles-ci, dans les zones susceptibles de donner lieu à un site antigénique pour les lymphocytes T. Le fragment Fv contient les domaines variables de l'immunoglobuline murine. La présente invention concerne également l'utilisation des anticorps recombinants dérivés de l'anticorps murin ior C5 pour le diagnostic et le traitement des tumeurs colorectales, de leurs métastases et de leurs récidives.

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