Antibodies of angiogenesis inhibiting domains of cd148

Details Antibodies of angiogenesis inhibiting domains of cd148 Antibodies of angiogenesis inhibiting domains of cd148

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2561823

Anti-CD148 antibodies and antigen-binding regions thereof, as well as pharmaceutical compositions comprising such antibodies and antigen-binding regions, are described. Also described are methods of using such antibodies and antigen-binding regions to bind CD148 epitopes and activate CD148 function, such as inhibition of angiogenesis. Epitopes that can be used to activate CD148 function and anti-angiogenesis activity are also described, as well as methods of identifying compounds that can bind them.

L'invention concerne des anticorps dirigés contre CD148 et des régions de liaison antigénique, ainsi que des compositions pharmaceutiques comprenant ces anticorps et ces zones de liaison antigénique. Cette invention concerne également des procédés d'utilisation desdits anticorps et zones de liaison antigénique pour fixer des déterminants antigéniques de CD148 et activer le fonctionnement de CD148, par exemple l'inhibition de l'angiogenèse. La présente invention concerne en outre des déterminants antigéniques pouvant être utilisés pour activer le fonctionnement de CD148 et l'activité anti-angiogenèse, ainsi que des procédés pour identifier des composés pouvant fixer lesdits déterminants antigéniques.

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