C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/00 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2420277
The present invention relates to the generation of methyllysine-specific histone antibodies. In particular, the H3 lysine 4 methylation specific antibody (Methyl(K4)H3) binds to histone H3 methylated at lysine 4. Methylation of lysine 4 (K4) on histone H3 has been associated with transcriptionally active regions of chromatin. A second antibody, H3 lysine 9 methylation specific antibody (Methyl(K9)H3) specifically binds to histone H3 methylated at lysine 9. Methylation of lysine 9 (K9) on histone H3 has been associated with gene silencing. These antibodies are useful in identifying regions of heterochromatin and euchromatin and serving as diagnostic and screening tools.
La présente invention concerne la production d'anticorps d'histone spécifiques à la méthyllysine. Plus particulièrement, l'anticorps spécifique de méthylation de H3 lysine 4 (méthyl(K4)H3) se fixe sur l'histone H3 méthylée en lysine 4. La méthylation de la lysine 4 (K4) sur l'histone H3 a été associée à des régions transcriptionnellement actives de la chromatine. Un second anticorps, appelé anticorps spécifique de méthylation de H3 lysine 9 (méthyl(K9)H3), se fixe spécifiquement sur l'histone H3 méthylée en lysine 9. La méthylation de la lysine 9 (K9) sur l'histone H3 a été associée à l'extinction des gènes. Ces anticorps sont utiles pour identifier des régions de l'hétérochromatine et de l'euchromatine, et peuvent être destinés au diagnostic et à l'analyse.
Allis C. David
Strahl Brian D.
Sim & Mcburney
University Of Virginia Patent Foundation
LandOfFree
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