C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/18 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2081990
ABSTRACT The present invention discloses methods for preparing antibodies which bind to specific isoforms of the human retinoic acid receptor-.gamma. (RAR-.gamma.). In addition, several monoclonal antibodies are described which bind to human RAR-.gamma., but not to mouse or which bind to RAR-.gamma.1, but not to RAR-.gamma.2. Methods and kits are described which allow one to detect the isotype of RAR-.gamma. which is expressed in a test sample. Such methods are useful in determining the tissue specific pattern of expression of various RAR-.gamma. isoforms. A138-16.WP5 092591
Chambon Pierre
Gaub Marie-Pierre
Lutz Yves
Rochette-Egly Cecille
Saunders Michael
Centre National de La Rescherche Scientifique
E.r. Squibb & Sons Inc.
Gowling Lafleur Henderson Llp
Institut National de La Sante Et de La Recherche Medicale
Universite Louis Pasteur Strasbourg I.
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