Antibodies that bind psca proteins for diagnosis of cancer

Details Antibodies that bind psca proteins for diagnosis of cancer Antibodies that bind psca proteins for diagnosis of cancer

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2742088

Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.

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