C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) G01N 33/52 (2006.01)
Patent
CA 2530272
The present invention relates to novel compositions and methods for regulating an immune response in a subject. More particularly, the invention relates to specific antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects. The invention also relates to fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly in therapy, to increase NK cell activity or cytotoxicity in subjects.
La présente invention a trait à de nouvelles compositions et de nouveaux procédés pour la régulation d'une réponse immunitaire chez un sujet. Plus particulièrement, l'invention a trait à des anticorps spécifiques qui assurent la régulation de l'activité des cellules NK et permettent la synergie de la cytotoxicité des cellules NK chez des sujets mammaliens. L'invention a trait en outre à des fragments et des dérivés de tels anticorps, ainsi qu'à des compositions pharmaceutiques les comprenant et leurs utilisations, notamment en thérapie, pour l'accroissement de l'activité ou de la cytotoxicité des cellules NK chez des sujets.
Andre Pascale
Chiesa Mariella Della
Gauthier Laurent
Moretta Alessandro
Padkjaer Soeren Berg
Dimock Stratton Llp
Innate Pharma S.a.s.
Novo Nordisk A/s
University Of Genoa
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