Antibodies to gdf8 as uses thereof

Details Antibodies to gdf8 as uses thereof Antibodies to gdf8 as uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/22 (2006.01)

Patent

CA 2704315

The disclosure provides novel molecules related to growth and differentiation factor 8 (GDF8), in particular epitopes spe-cific to GDF8 and other specific antagonists of GDF8 in particular anti GDF8 antibodies or antigen binding protein or fragment thereof that may inhibit GDF8 activity and signal in vitro and/or in vivo. The dis-closure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, prevent-ing, ameliorating, and treating GDF8 associated disorders, e.g., de-generative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such dis-orders by using the antibodies, polypeptides, polynucleotides, and vec-tors of the invention.

L'invention porte sur de nouvelles molécules se rapportant au facteur 8 de croissance et de différenciation (GDF8), en particulier aux épitopes spécifiques de GDF8 et autres antagonistes spécifiques de GDF8 en particulier des anticorps anti-GDF8 ou une protéine de liaison à un antigène ou à un fragment de celle-ci qui peuvent inhiber l'activité et le signal de GDF8 in vitro et/ou in vivo. L'invention porte également sur un immunoessai utilisé pour détecter et quantifier GDF8. L'invention porte également sur des procédés de diagnostic, de prévention, d'amélioration et de traitement de troubles associés au GDF8, par exemple les troubles dégénératifs du muscle, de l'os et du métabolisme de l'insuline. Enfin, l'invention porte sur des produits pharmaceutiques pour le traitement de tels troubles à l'aide des anticorps, polypeptides, polynucléotides et vecteurs de l'invention.

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