Antibodies with enhanced adcc function

Details Antibodies with enhanced adcc function Antibodies with enhanced adcc function

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) G01N 33/569 (2006.01) C12N 9/10 (2006.01) C12N 9/24 (2006.01)

Patent

CA 2717614

The present invention concerns a mammalian cell lacking G1cNAc transferase I activity, engineered to express an antibody or a fragment thereof, thereby enhancing the antibody dependent cell mediated cytotoxicity (ADCC) exhibited by the expressed antibody or fragment thereof.

La présente invention concerne une cellule mammifère ne présentatn pas d'activité de transférase I GlcNAc, conçue pour exprimer un anticorps ou un de ses fragments, tout en améliorant la cytotoxicité à médiation cellulaire dépendante d'un anticorps (ADCC) exposée dans l'anticorps exprimé ou son fragment.

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