Antidiabetic bicyclic compounds

Details Antidiabetic bicyclic compounds Antidiabetic bicyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 307/93 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61P 3/10 (2006.01) C07C 62/34 (2006.01) C07C 229/50 (2006.01) C07D 213/64 (2006.01) C07D 333/78 (2006.01)

Patent

CA 2651153

Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

L'invention concerne des composés tricycliques comportant un acide carboxylique de cyclopropyle ou un dérivé de cet acide carboxylique (par ex. un amide) condensé avec un anneau bicyclique, ainsi que des sels pharmaceutiquement acceptables et des promédicaments de ces composés, qui constituent des agonistes du récepteur couplé à la protéine G 40 (GPR40) et peuvent servir de composés thérapeutiques, en particulier pour traiter le diabète sucré de type 2, ainsi que des états qui sont souvent associés à cette maladie, parmi lesquels figurent l'obésité et les troubles lipidiques tels que la dyslipidémie mixte ou diabétique, l'hyperlipidémie, l'hypercholestérolémie, et l'hypertriglycéridémie.

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