Antifungal agents

Details Antifungal agents Antifungal agents

C - Chemistry, Metallurgy

07

J

C07J 71/00 (2006.01) A61K 31/58 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2649432

The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (l,3)-.beta.-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.

La présente invention concerne de nouveaux dérivés d'enfumafungine de formule I et leurs sels pharmaceutiquement acceptables, leur synthèse et leur utilisation comme inhibiteurs de la (1,3)-$-D-glucane synthase. Les présents composés et leurs sels pharmaceutiquement acceptables, ainsi que les compositions pharmaceutiques comprenant les présents composés et leurs sels pharmaceutiquement acceptables, sont utiles pour le traitement ou la prévention d'infections antifongiques et de maladies et états associés.

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