C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 35/18 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2183535
Constructs consisting of antigen-based heteropolymers (AHP's) are provided. The antigen-based heteropolymers comprise at least one monoclonal antibody specific for binding to complement receptor (CR1) site on a human or non-human primate erythrocyte, and the anti-CR1 monoclonal antibody is cross-linked to an antigen specific for a target pathogenic autoantibody. Further provided is a method for treating antoimmune diseases in human or non-human primates using the AHP.
L'invention concerne des produits de recombinaison constitués d'hétéropolymères à base d'antigen (AHP). Les hétéropolymères à base d'antigènes comprennent au moins un anticorps monoclonal se fixant spécifiquement au site récepteur du complément (CR1) sur un éthythrocyte humain ou de primate, et l'anticorps monoclonal anti-CR1 est réticulé en un antigène spécifique à un auto-anticorps pathogène cible. L'invention concerne également un procédé de traitement de maladies autoimmunes chez l'homme ou chez des primates, utilisant les AHP.
Ferguson Polly J.
Greene Kirsten
Johnson Cyd
Martin Edward N.
Reist Craig J.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
University Of Virginia Alumni Patents Foundation (the)
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