Antigenic protein originating in malassezia

Details Antigenic protein originating in malassezia Antigenic protein originating in malassezia

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/35 (2006.01) C07H 21/00 (2006.01) C07K 14/37 (2006.01) C07K 16/14 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2238278

A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.

La présente invention concerne une protéine antigénique isolée sensiblement pure, provenant de champignons du genre Malassezia, caractérisée par son avidité d'anticorps IgE provenant de patients allergiques; l'invention concerne aussi des fragments antigéniques provenant de cette protéine, un anticorps spécifique opposé à cette protéine antigénique ou à ces fragments, un agent diagnostique, thérapeutique ou prophylactique pour les maladies liées à la Malassezia, agent ayant pour constituant actif la protéine antigénique pu des fragments, une protéine antigénique recombinante nouvelle provenant de la Malassezia, un codage de gènes pour la protéine et des épitopes de la protéine.

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