Antigens and methods therefor

Details Antigens and methods therefor Antigens and methods therefor

C - Chemistry, Metallurgy

12

N

530/13, 167/134,

C12N 15/51 (2006.01) A61K 39/29 (2006.01) C07K 14/02 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/81 (2006.01) C12P 21/02 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2021762

A composite particle comprising at least two polypeptides corresponding to all or part of a protein having the biological activity of one of the hepatitis B surface antigens, wherein the particle presents at least two antigenic determinants provided by the S-protein, preS2-protein or preS1-protein, said particle optionally further comprising host specific lipids. The invention also provides a modified hepatitis B surface antigen L protein which may be used alone or incorporated into such composite particles. A particular embodiment of the modified L protein (L*) comprises residues 12-52 followed by residues 133-145 followed by residues 175-400 of the L protein and a particular embodiment of a composite particle has the form (L*, S) where S is the S-protein of HBsAg. Improved hepatitis B vaccines may be prepared following expression of the above immunogens, especially in yeasts such as S. cerevisiae and Hansenula polymorpha.

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