Antihypertensive agents, pharmaceutical compositions...

Details Antihypertensive agents, pharmaceutical compositions... Antihypertensive agents, pharmaceutical compositions...

C - Chemistry, Metallurgy

07

K

260/284, 530/5.0

C07K 5/06 (2006.01) A61K 37/02 (1990.01)

Patent

CA 1276396

ABSTRACT (Benzothiadiazine, benzamido and benzene- sulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds. Compounds of this invention are useful as antihypertensive agents and for the treatment of glaucoma. The dipeptide compounds are represented by the formula Image wherein W is Image II III IV V n is 0 or 1; m is 0 to 2; p and q are each 0, 1 or 2, provided that the sum of p and q is 1 or 2, and that in formula V, p is not 0; Y is -CH2-, -CH2O-, or -CH2S-, attached at the 2 or 4 position of phenyl group; Z is Image VI VII wherein A is Cl or CP3; D is -(CH2)u-, -CH2O-, -CH2S-; Image G is -CONR7(CH2)t-, or -SO2NR7(CH2)t-; to is 0 or 1. For the definition of R1, R2, R3, R4, R5, R6, R7, R8 and R9 reference is made to the specification.

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