Antipsychotic cyclic n-aralkylamines

Details Antipsychotic cyclic n-aralkylamines Antipsychotic cyclic n-aralkylamines

C - Chemistry, Metallurgy

07

D

C07D 295/06 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) C07D 295/02 (2006.01) C07D 295/03 (2006.01) C07D 295/073 (2006.01) C07D 295/08 (2006.01) C07D 295/096 (2006.01)

Patent

CA 2376691

The invention concerns antipsychotic compounds of formula (I) wherein: A represents a group selected among the following: -CaC-; -CH=CH-; -CH2-CH2-; n is equal to 1 or 2; X represents a hydrogen, chlorine or fluorine atom, a methyl or methoxy group; Y represents a hydrogen atom or a chlorine or a fluorine atom; R1 represents a cyclohexyl, phenyl, cycloheptyl, tertiary butyl, dicyclopropylmethyl, bicyclo[3.2.1]octanyl, 4-tetrahydropyranyl, 4- tetrahydrothiopyranyl or adamantyle group; R2 and R3 form together with the nitrogen atom whereto they re bound a cyclic amine; and the additive salts of said compounds with pharmaceutically acceptable acids, as well as their solvates and hydrates.

Composès antipsychotiques de formule (I) dans laquelle: A représente un groupe choisi parmi les suivants: -C=C-; -CH=CH-, -CH2-CH2-; n est égal à 1 ou 2; X représente un atome d'hydrogène, de chlore ou de fluor ou un groupe méthyle ou méthoxy; Y représente un atome d'hydrogène ou un atome de chlore ou de fluor; R1 représente un groupe cyclohexyle phényle cycloheptyle, <i>tert</i>-butyle, dicyclopropylméthyle, bicyclo[3.2.1]octanyle, 4-tétrahydropyranyle, 4-tétrahydrothiopyranyle ou adamantyle; R2 et R3 forment avec l'atome d'azote auquel ils sont liés une amine cyclique et les sels d'addition de ces composés avec des acides pharmaceutiquement acceptables, ainsi que leurs solvats et hydrates.

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