C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2251945
The present invention relates to the inhibition of vascular endothelial growth factor expression with oligonucleotides. The oligonucleotides of the present invention are thought to bind to target nRNA in a sequence specific manner and prevent expression of the encoded gene. Chemical modifications of the oligonucleotides for increasing their stability and binding efficiency are disclosed. These modifications increase the stability and the efficiency of the oligonucleotides contemplated in this invention. Oligonucleotides compositions can be used in ex vivo therapies for the treatment of macrophages or in vivo therapies by injection, inhalation, topical treatment or other routes of administration.
L'invention concerne l'inhibition de l'expression du facteur de croissance endothéliale vasculaire au moyen d'oligonucléotides. On pense que ces oligonucléotides se fixent à l'ARNm cible selon une séquence spécifique et empêchent l'expression du gène codé. L'invention concerne les modifications chimiques des oligonucléotides afin d'augmenter leur stabilité et leur efficacité de fixation. Ces modifications augmentent la stabilité et l'efficacité de ces oligonucléotides. On peut utiliser des compositions à base d'oligonucléotides dans des thérapies ex vivo pour le traitement de macrophages ou dans des thérapies in vivo par injection, inhalation, traitement localisé ou autres voies d'administration.
Chaudhary Nilabh
Cossum Paul A.
Peyman Anusch
Rando Robert F.
Rao T. Sudhakar
Aronex Pharmaceuticals Inc.
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Marion Roussel Deutschland Gmbh
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