Antisense oligonucleotides that inhibit expression of hif-1

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 21/04 (2006.01) A61K 31/7125 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2513398

New antisense oligonucleotide compounds, RX-0047 and RX-0149, inhibit expression of HIF-1 and also induce cytotoxicity in several cancer cell lines.

L'invention concerne de nouveaux composés oligonucléotidiques anti-sens, RX-0047 et RX-0149, qui inhibent l'expression du HIF-1 et induisent également une cytotoxicité dans plusieurs lignées cellulaires cancéreuses.

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