Antitumor compositions and methods of treatment

A - Human Necessities – 61 – K

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A61K 31/47 (2006.01) C07D 471/06 (2006.01)

Patent

CA 2111902

Abstract This invention provides a series of novel substituted 7H-benzimidazo[2,1-a]benz[de]isoquinoline-7-ones, and the pharmaceutically acceptable salts or solvates thereof. This invention further provides methods of treating susceptible neoplasms in mammals using these 7H- benz1midazo[2,1-a]benz[de]isoquinoline-7-ones. This invention additionally provides novel pharmaceutical formulations comprising one or more of the compounds of this invention in combination with pharmaceutically acceptable diluents, excipients and carriers.

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