C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 15/00 (2006.01) A61K 31/282 (2006.01)
Patent
CA 2370692
The present invention relates to an antitumor derivative of double dicarboxylic acid diaminoplatin complex of formula I: (see formula I) wherein R1 and R2 have the meanings defined in the specification, also relates to a process for preparation thereof, to an antitumor pharmaceutical composition containing the same, and further to application of the derivative in making antitumor pharmaceutics. The composition is a new generation of safe and effective antitumor drug, which has advantages such as low toxicity, broad antitumor spectrum, high antitumor activity, good solubility in water and fine stability in aqueous solution, selective killing of cancer cells without damaging normal cells, etc.
L'invention concerne un dérivé de carboxylate de complexes de (diamine)platine de formule (I), dans laquelle R<1> et R<2> sont tels que définis dans le descriptif. L'invention concerne en outre le procédé de préparation de ces dérivés et les compositions thérapeutiques anticancéreuses contenant ces dérivés. Ces compositions présentent l'avantage d'être peu toxiques, de trouver une vaste application anticancéreuse, d'avoir une forte action anticancéreuse, des bonnes solubilité et stabilité tout en sélectionnant les cellules à détruire sans pour autant endommager les cellules normales. Ce nouveau médicament est, de ce fait, considéré comme sûr et efficace.
Cui Weichuan
Wang Jingzun
Yang Jinli
Yang Xuqing
Yang Zhenyun
Goudreau Gage Dubuc
Yang Xuqing
LandOfFree
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